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Aflatoxin Activation and Detoxification
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5423646).
Statements about
Aflatoxin Activation and Detoxification
Instance Of
Biological Pathway
Aflatoxin Metabolic Process
Part Of
Biological Oxidations
Has Part(s)
18 items
CYP3A4,5 Hydroxylates AFB1 to AFQ1
CYP1A2 Hydroxylates AFB1 to AFM1
CYP2A13 Oxidises AFM1 to AFM1E
CYP1A2,3A4,3A5,2A13 Oxidise AFB1 to AFXBO
CYP1A2, 3A4 Oxidise AFB1 to AFNBO
AFXBO Translocates From Cytosol to Nucleoplasm
AFXBO Binds DNA
MGST Trimers Transfer GS From GSH to AFXBO and AFNBO
AFXBO-SG, AFNBO-SG Translocate From Cytosol to Extracellular Region
GGTs Hydrolyse Glutamate From AFXBO-SG, AFNBO-SG
DPEPs Hydrolyse Glycine From AFXBO-CG, AFNBO-CG
AFXBO-C, AFNBO-C Translocate From Extracellular Region to Cytosol
Unknown NAT Transfers COCH3 to AFXBO-C, AFNBO-C
ACY1:Zn2+ Dimer Hydrolyses Mercapturic Acids
AFXBO Hydrolyses Non-Enzymatically to AFBDHD
AFBDHD Hydrolyses Non-Enzymatically to AFBDHO
AKR Dimers Reduce AFBDHO to AFBDOH
ACY3:Zn2+ Dimer Hydrolyses Mercapturic Acids
Exact Match
https://identifiers.org/reactome:R-H ...
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