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Heme Degradation - Ontify

Heme Degradation

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-189483).

Statements about Heme Degradation

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Instance Of

Biological Pathway

Heme Catabolic Process

Part Of

Metabolism of Porphyrins

Has Part(s)

22 items

HMOX1 Dimer, HMOX2 Cleave Heme

BLVRA:Zn2+, BLVRB Reduce BV to BIL

BIL Translocates From the Cytosol to the ER Lumen

UGT1A4 Transfers GlcA From UDP-GlcA to BIL to Form BMG

UGT1A4 Transfers GlcA From UDP-GlcA to BMG to Form BDG

ABCC1 Transports BIL From Cytosol to Extracellular Region (Blood)

BIL:ALB Dissociates

SLCO1B1 Transports BIL From Extracellular Region (Blood) to Cytosol (Hepatocyte)

SLCO2B1-3 Transports BIL From Extracellular Region (Blood) to Cytosol (Hepatocyte)

SLCO1B3 Transports BIL From Extracellular Region (Blood) to Cytosol (Hepatocyte)

BIL Binds GSTA1, FABP1

BIL Dissociates From GSTA1, FABP1

BMG, BDG Translocates From ER Lumen to Cytosol

ABCC2 Transports BMG,BDG From Cytosol to Extracellular Region

ABCG2 Tetramer Transports BMG,BDG From Cytosol to Extracellular Region

Bacterial GUSB Hydrolyses BDG to BIL

An Unknown BILR Reduces BIL to D-UBGN

An Unknown Reductase Reduces D-UBGN to STBN

An Unknown Oxidase Oxidises D-UBGN to UBN

UGT1A1 Transfers GlcA From UDP-GlcA to BIL to Form BMG

UGT1A1 Tetramer Transfers GlcA From UDP-GlcA to BMG to Form BDG

Exact Match

https://identifiers.org/reactome:R-H ...