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Tryptophan Catabolism - Ontify

Tryptophan Catabolism

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-71240).

Statements about Tryptophan Catabolism

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Instance Of

Biological Pathway

Tryptophan Catabolic Process

Has Part(s)

16 items

SLC7A5:SLC3A2 Transports Neutral Amino Acids From Extracellular Region to Cytosol

Kynurenine + 2-Oxoglutarate => 4-(2-Aminophenyl)-2,4-Dioxobutanoic Acid + Glutamate

Exact Match

https://identifiers.org/reactome:R-H ...

Part Of

Metabolism of Amino Acids and Derivatives

IDO2 Dioxygenates L-Trp to NFK

TDO Tetramer Dioxygenates L-Trp to NFK

3-Hydroxyanthranilate + O2 => 2-Amino-3-Carboxymuconate Semialdehyde

SLC36A4 Transports L-Trp From Extracellular Region to Cytosol

IDO1 Dioxygenates L-Trp to NFK

AFMID Hydrolyses NFK to L-KYN

PXLP-KYAT1 Dimer Transaminates L-KYN to AP-DOBu

4-(2-Aminophenyl)-2,4-Dioxobutanoate => Kynurenic Acid + H2O [Mitochondrial]

2-Aminomuconate Semialdehyde + NAD+ + H2O => Aminomuconate + NADH + H+

3-Hydroxykynurenine + H2O => 3-Hydroxyanthranilate + Alanine

2-Amino-3-Carboxymuconate Semialdehyde => 2-Aminomuconate Semialdehyde + CO2

Kynurenine + O2 + NADPH + H+ => 3-Hydroxykynurenine + NADP+ + H2O

4-(2-Aminophenyl)-2,4-Dioxobutanoate => Kynurenic Acid + H2O [Cytosolic]

Kynurenine + Pyruvate => 4-(2-Aminophenyl)-2,4-Dioxobutanoic Acid + Alanine [CCBL2]