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Lysine Catabolism - Ontify

Lysine Catabolism

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-71064).

Statements about Lysine Catabolism

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Instance Of

Biological Pathway

Lysine Catabolic Process

Has Part(s)

13 items

PXLP-K278-PHYKPL Tetramer Hydrolyses 5PHL

Exact Match

https://identifiers.org/reactome:R-H ...

Part Of

Metabolism of Amino Acids and Derivatives

Saccharopine + NAD+ + H2O => Alpha-Aminoadipic Semialdehyde + Glutamate + NADH + H+

CRYM Reduces P2C to PPCA

Lysine + Alpha-Ketoglutarate +NADPH + H+ => Saccharopine + NADP+ + H2O

Alpha-Aminoadipoate Semialdehyde + NAD+ => Alpha-Aminoadipate + NADH + H+

PIPOX Oxidises PPCA to P6C

Glutaryl-CoA + FAD => Crotonyl-CoA + FADH2 + CO2

Alpha-Ketoadipate + CoASH + NAD+ => Glutaryl-CoA + CO2 + NADH + H+

P6C Transforms to 2AMAS

Alpha-Ketoadipate + Glutamate <=> Alpha-Aminoadipate + Alpha-Ketoglutarate

HYKK Phosphorylates 5HLYS

2-Oxoglutarate [Mitochondrial Matrix] + 2-Oxoadipate [Cytosol] <=> 2-Oxoglutarate [Cytosol] + 2-Oxoadipate [Mitochondrial Matrix]

Alpha-Aminoadipate + Alpha-Ketoglutarate <=> Alpha-Ketoadipate + Glutamate