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Branched-Chain Amino Acid Catabolism - Ontify
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Branched-Chain Amino Acid Catabolism
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-70895).
Statements about
Branched-Chain Amino Acid Catabolism
Instance Of
Biological Pathway
Branched-Chain Amino Acid Catabolic Process
Part Of
Metabolism of Amino Acids and Derivatives
Has Part(s)
23 items
BCKDH Transfers CoA Group From CoA-SH to BCAAs
BCKDK Phosphorylates BCKDH
PPM1K Dephosphorylates P-BCKDH
Exact Match
https://identifiers.org/reactome:R-H ...
Methylmalonyl Semialdehyde + NADH + H+ <=> Beta-Hydroxyisobutyrate + NAD+
Alpha-Methylbutyryl-CoA + FAD => Tiglyl-CoA + FADH2
Isobutyryl-CoA + FAD => Methacrylyl-CoA + FADH2
A-Ketoisocaproate, A-Keto-B-Methylvalerate, or A-Ketoisovalerate + Glutamate <=> Leu, Ile, or Val + Alpha-Ketoglutarate [BCAT1]
Alpha-Methyl-Acetoacetyl-CoA + CoA => Propionyl-CoA + Acetyl-CoA
ECHS1 Hydrates Methacrylyl-CoA
Beta-Hydroxyisobutyrate + NAD+ <=> Methylmalonyl Semialdehyde + NADH + H+
Methylmalonate Semialdehyde + NAD+ + CoA => Propionyl-CoA + CO2 + NADH + H+
Leu, Ile, or Val + Alpha-Ketoglutarate <=> A-Ketoisocaproate, A-Keto-B-Methylvalerate, or A-Ketoisovalerate + Glutamate [BCAT1]
A-Ketoisocaproate, A-Keto-B-Methylvalerate, or A-Ketoisovalerate + Glutamate <=> Leu, Ile, or Val + Alpha-Ketoglutarate [BCAT2]
Beta-Methylglutaconyl-CoA + ADP + Orthophosphate + H2O <=> Beta-Methylcrotonyl-CoA + ATP + CO2 [MCCA]
Beta-Methylglutaconyl-CoA + H2O <=> Beta-Hydroxy-Beta-Methylglutaryl-CoA
Beta-Hydroxyisobutyryl-CoA + H2O => Beta-Hydroxyisobutyrate + CoA
SLC25A44 Transports Leu, Ile and Val From Cytosol to Mitochondrial Matrix
Tiglyl-CoA + H2O <=> Alpha-Methyl-Beta-Hydroxybutyryl-CoA
Alpha-Methylacetoacetyl-CoA + NADH + H+ <=> Alpha-Methyl-Beta-Hydroxybutyryl-CoA + NAD+
Leu, Ile, or Val + Alpha-Ketoglutarate <=> A-Ketoisocaproate, A-Keto-B-Methylvalerate, or A-Ketoisovalerate + Glutamate [BCAT2]
Isovaleryl-CoA + FAD => Beta-Methylcrotonyl-CoA + FADH2
Beta-Methylcrotonyl-CoA + ATP + CO2 <=> Beta-Methylglutaconyl-CoA + ADP + Orthophosphate + H2O [MCCA]
Alpha-Methyl-Beta-Hydroxybutyryl-CoA + NAD+ <=> Alpha-Methylacetoacetyl-CoA + NADH + H+
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