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Metabolism of Folate and Pterines
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-196757).
Statements about
Metabolism of Folate and Pterines
Instance Of
Biological Pathway
Folic Acid Metabolic Process
Part Of
Metabolism of Water-Soluble Vitamins and Cofactors
Has Part(s)
31 items
FOLR2 Binds FOLA
FOLR2 Transports FOLA From Extracellular Region to Cytosol
SLC46A1 Transports FOLA From Extracellular Region to Cytosol
Cytosolic Folate Export Across the Plasma Membrane
SLC19A1 Transports 5-Methyl-THF From Extracellular Region to Cytosol
DHFR2 Reduces FOLA to DHF
DHF Is Reduced to Tetrahydrofolate (THF)
FPGS-2 Transforms THF to THFPG
FPGS-2 Transforms 5-Methyl-THF to 5-Methyl-THFPG
SLC25A32 Transports THF From Cytosol to Mitochondrial Matrix
SLC25A32 Transports THF From Mitochondrial Matrix to Cytosol
Mitochondrial FPGS-1 Transforms THF to THFPG
PXLP-K280-SHMT2 Tetramer Transfers CH2OH Group to Gly to Form L-Ser
MTHFD1L Dimer Ligates HCOOH to THF to Form 10-Formyl-THF
MTHFD1 Dimer Ligates HCOOH to THFPG to Form 10-Formyl-THFPG
MTHFD1 Dimer Transforms 10-Formyl-THFPG to 5,10-Methenyl-THFPG
MTHFD1 Dimer Dehydrogenates 5,10-Methenyl-THFPG to 5,10-Methylene-THFPG
SHMT1 Tetramer Transfers Hydroxymethyl Group to THFPG to Form 5,10-Methylene-THFPG
MTHFR Dimer Reduces 5,10-Methylene-THFPG to 5-Methyl-THFPG
5,10-methyleneTHF Polyglutamate + Glycine <=> Tetrahydrofolate Polyglutamate (THF Polyglutamate) + Serine
5,10-methyleneTHF Polyglutamate + NADP+ <=> 5,10-methenylTHF Polyglutamate + NADPH + H+
5,10-methenylTHF Polyglutamate + H2O <=> 10-formylTHF Polyglutamate
ALDH1L1 Dehydrogenates 10-Formyl-THFPG to THFPG
MTHFD2, D2L Oxidise 5,10-Methylene-THF to 5,10-Methenyl-THF
MTHFD2, D2L Oxidise 5,10-Methenyl-THF to 10-Formyl-THF
ALDH1L2 Dehydrogenates 10-Formyl-THFPG to THFPG
MTHFS Transforms 5-Formyl-THFPG to 5,10-Methenyl-THFPG
MTHFD1L Transforms 10-Formyl-THF to HCOOH and THF
HCOOH Translocated From Mitochondrial Matrix to Cytosol
DHFR Dimer Reduces FOLA to DHF
DHFR Dimer Binds DHFR Inhibitors
Exact Match
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