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Purine Ribonucleoside Monophosphate Biosynthesis - Ontify

Purine Ribonucleoside Monophosphate Biosynthesis

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-73817).

Statements about Purine Ribonucleoside Monophosphate Biosynthesis

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Instance Of

Biological Pathway

Purine Ribonucleoside Monophosphate Biosynthetic Process

Part Of

Nucleotide Biosynthesis

Has Part(s)

17 items

Formation of Phosphoribosyl Pyrophosphate Amidotransferase Tetramer

Dissociation of Phosphoribosyl Pyrophosphate Amidotransferase Tetramer

5-Phospho-Alpha-D-Ribose 1-Diphosphate (PRPP) + H2O + L-Glutamine <=> 5-Phosphoribosylamine + L-Glutamate +Pyrophosphate

5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi

GAR + 10-Formyl-THF => FGAR + THF

FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

FGAM + ATP => AIR + ADP + Pi

AIR + CO2 => CAIR

CAIR + Aspartate + ATP => SAICAR + ADP + Pi

SAICAR => AICAR + Fumarate

AICAR + 10-Formyl-THF => FAICAR + THF

FAICAR => IMP + H2O

IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]

XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + Pyrophosphate

IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

Adenylosuccinate => Adenosine 5'-Monophosphate + Fumarate

IMPDH Tetramers Binds IMPDH Inhibitors

Exact Match

https://identifiers.org/reactome:R-H ...