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Citric Acid Cycle (TCA Cycle) - Ontify
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Citric Acid Cycle (TCA Cycle)
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-71403).
Statements about
Citric Acid Cycle (TCA Cycle)
Instance Of
Biological Pathway
Tricarboxylic Acid Cycle
Part Of
Pyruvate Metabolism and Citric Acid (TCA) Cycle
Has Part(s)
17 items
Alpha-Ketoglutarate + CoASH + NAD+ => Succinyl-CoA + CO2 + NADH + H+
Exact Match
https://identifiers.org/reactome:R-H ...
(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+
Citrate <=> Isocitrate
(S)-Malate <=> Fumarate + H2O
NADPH + NAD+ + H+ [Cytosol] => NADP+ + NADH + H+ [Mitochondrial Matrix]
Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA
Isocitrate + NADP+ => Alpha-Ketoglutarate + CO2 + NADPH + H+ [IDH2]
Isocitrate <=> Citrate
GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA
Succinate <=> Fumarate (with FAD Redox Reaction on Enzyme)
Fumarate + H2O <=> (S)-Malate
Isocitrate + NAD+ => Alpha-Ketoglutarate + CO2 + NADH + H+ [IDH3]
ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA
FAHD1:Zn2+ Dimer Hydrolyses OA to PYR
ME3:Mg2+ Tetramer Oxidatively Decarboxylates MAL to PYR
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+
ME2:Mg2+ Tetramer Oxidatively Decarboxylates MAL to PYR
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