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Tetrahydrobiopterin (BH4) Synthesis, Recycling, Salvage and Regulation - Ontify

Tetrahydrobiopterin (BH4) Synthesis, Recycling, Salvage and Regulation

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1474151).

Statements about Tetrahydrobiopterin (BH4) Synthesis, Recycling, Salvage and Regulation

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Instance Of

Biological Pathway

Tetrahydrobiopterin Metabolic Process

Has Part(s)

16 items

GCH1 Reduces GTP to Dihydroneopterin Triphosphate

PTPS Is Phosphorylated by cGMP-Dependant Protein Kinase II

DHNTP Is Dephosphorylated by PTPS to PTHP

Sepiapterin Reductase (SPR) Is Phosphorylated by Ca2+/Calmodulin-Dependent Protein Kinase II

PTHP Is Reduced to BH4 by Sepiapterin Reductase (SPR)

BH4 Is Oxidised to the BH3 Radical During the eNOS Catalytic Cycle

Peroxynitrite Can Oxidise BH4 to the BH3 Radical

Ferrous Iron Reduces the BH3 Radical Back to BH4

Ascorbate Can Reduce the BH3 Radical Back to BH4

The BH3 Radical Can Decay to Dihydrobiopterin (BH2)

BH2 Binding Can Lead to eNOS Uncoupling

GCHFR Binds to GCH1 and Negatively Regulates Its Activity

Salvage - Sepiapterin Is Reduced to BH2

Salvage - BH2 Is Reduced to BH4 by DHFR

The Cofactor BH4 Is Required for Electron Transfer in the eNOS Catalytic Cycle

Unknown Sepiapterin Synthase Transforms PTHP to Sepiapterin

Exact Match

https://identifiers.org/reactome:R-H ...

Part Of

Metabolism of Cofactors