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Synthesis of Bile Acids and Bile Salts via 24-Hydroxycholesterol - Ontify
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Synthesis of Bile Acids and Bile Salts via 24-Hydroxycholesterol
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-193775).
Statements about
Synthesis of Bile Acids and Bile Salts via 24-Hydroxycholesterol
Instance Of
Biological Pathway
Bile Acid Biosynthetic Process
Part Of
Synthesis of Bile Acids and Bile Salts
Has Part(s)
28 items
CYP46A1 24-Hydroxylates CHOL
CYP39A1 7-Hydroxylates 24OH-CHOL
Exact Match
https://identifiers.org/reactome:R-H ...
3,7,24THCA-CoA Is Translocated From the Cytosol to the Peroxisome
3,7,24THCA Is Translocated From the Mitochondrial Matrix to the Cytosol
5beta-Cholestan-3alpha,7alpha,12alpha,24(S)-Tetrol Is Translocated From the Cytosol to the Mitochondrial Matrix
5Beta-Cholestan-7alpha,12alpha,24(S)-Triol-3-One Is Reduced to 5beta-Cholestan-3alpha,7alpha,12alpha,24(S)-Tetrol
3,7,24THCA Is Conjugated with Coenzyme A (SLC27A5 BACS)
Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-Cholestanoyl-CoA
3,7,24THCA Is Conjugated with Coenzyme A (SLC27A2 VLCS)
4-Cholesten-7alpha,12alpha,24(S)-Triol-3-One Is Reduced to 5beta-Cholestan-7alpha,12alpha,24(S)-Triol-3-One
Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-Trihydroxy-5beta-Cholestanoyl-CoA
3alpha,7alpha,12alpha,24(S)-Tetrahydroxy-5beta-Cholestan-27-Al Is Oxidized to 3alpha,7alpha,12alpha,24(S)-Tetrahydroxy-5beta-Cholestanoate (TetraHCA)
3alpha,7alpha,24(S)-Trihydroxy-5beta-Cholestan-27-Al Is Oxidized to 3alpha,7alpha,24(S)-Trihydroxy-5beta-Cholestanoate (3,7,24THCA)
5beta-Cholestan-3alpha,7alpha,24(S)-Triol Is Translocated From the Cytosol to the Mitochondrial Matrix
CYP8B1 12-Hydroxylates 4CHOL7a,24(S)DIOL
TetraHCA Is Conjugated with Coenzyme A (SLC27A5 BACS)
TetraHCA Is Translocated From the Mitochondrial Matrix to the Cytosol
5beta-Cholestan-3alpha,7alpha,12alpha,24(S),27-Pentol Is Oxidized to 3alpha,7alpha,12alpha,24(S)-Tetrahydroxy-5beta-Cholestan-27-Al
Efflux of 24-Hydroxycholesterol
Influx of 24-Hydroxycholesterol
5beta-Cholestan-3alpha,7alpha,24(S),27-Tetrol Is Oxidized to 3alpha,7alpha,24(S)-Trihydroxy-5beta-Cholestan-27-Al
5beta-Cholestan-3alpha,7alpha,12alpha,24(S)-Tetrol Is Hydroxylated to 5beta-Cholestan-3alpha,7alpha,12alpha,24(S), 27-Pentol
5beta-Cholestan-7alpha,24(S)-Diol-3-One Is Reduced to 5beta-Cholestan-3alpha,7alpha,24(S)-Triol
TetraHCA Is Conjugated with Coenzyme A (SLC27A2 VLCS)
25(R) TetraHCA-CoA Is Translocated From the Cytosol to the Peroxisome
4-Cholesten-7alpha,24(S)-Diol-3-One Is Reduced to 5beta-Cholestan-7alpha,24(S)-Diol-3-One
CYP27A1 27-Hydroxylates 5β-CHOL3α,7α,24(s)-Triol
Cholest-5-Ene-3beta,7alpha,24(S)-Triol Is Oxidized and Isomerized to 4-Cholesten-7alpha,24(S)-Diol-3-One
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