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Synthesis of Bile Acids and Bile Salts via 7alpha-Hydroxycholesterol - Ontify

Synthesis of Bile Acids and Bile Salts via 7alpha-Hydroxycholesterol

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-193368).

Statements about Synthesis of Bile Acids and Bile Salts via 7alpha-Hydroxycholesterol

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Instance Of

Biological Pathway

Bile Acid Biosynthetic Process

Part Of

Synthesis of Bile Acids and Bile Salts

Has Part(s)

39 items

CYP7A1 7-Hydroxylates CHOL

7alpha-Hydroxycholesterol Is Oxidized and Isomerized to 4-Cholesten-7alpha-Ol-3-One

CYP8B1 12-Hydroxylates 4CHOL7aOLONE

4-Cholesten-7alpha, 12alpha-Diol-3-One Is Reduced to 5beta-Cholesten-7alpha, 12alpha-Diol-3-One

4-Cholesten-7alpha-Ol-3-One Is Reduced to 5beta-Cholestan-7alpha-Ol-3-One

5Beta-Cholesten-7alpha, 12alpha-Diol-3-One Is Reduced to 5beta-Cholestan-3alpha, 7alpha, 12alpha-Triol

5beta-Cholestan-7alpha-Ol-3-One Is Reduced to 5beta-Cholestan-3alpha, 7alpha-Diol

5beta-Cholestan-3alpha, 7alpha, 12alpha-Triol Is Translocated From the Cytosol to the Mitochondrial Matrix

5beta-Cholestan-3alpha, 7alpha-Diol Is Translocated From the Cytosol to the Mitochondrial Matrix

CYP27A1 27-Hydroxylates 5bCHOL3a,7a,12a-Triol

5beta-Cholestan-3alpha,7alpha,12alpha,27-Tetrol Is Oxidized to 3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-27-Al

5beta-Cholestan-3alpha, 7alpha-Diol Is Hydroxylated to 5beta-Cholestan-3alpha, 7alpha, 26-Triol

5beta-Cholestan-3alpha, 7alpha, 26-Triol Is Oxidized to 3alpha, 7alpha-Dihydroxy-5beta-Cholestan-26-Al

3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-27-Al Is Oxidized to 3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestanoate (THCA)

3alpha, 7alpha-Dihydroxy-5beta-Cholestan-26-Al Is Oxidized to 3alpha, 7alpha-Dihydroxy-5beta-Cholestanoate (DHCA)

THCA Is Translocated From the Mitochondrial Matrix to the Cytosol

DHCA Is Translocated From the Mitochondrial Matrix to the Cytosol

THCA Is Conjugated with Coenzyme A (SLC27A2 VLCS)

DHCA Is Conjugated with Coenzyme A (SLC27A2 VLCS)

THCA Is Conjugated with Coenzyme A (SLC27A5 BACS)

DHCA Is Conjugated with Coenzyme A (SLC27A5 BACS)

25(R) THCA-CoA Is Translocated From the Cytosol to the Peroxisome

25(R) DHCA-CoA Is Translocated From the Cytosol to the Peroxisome

Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA

Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA

25(S) THCA-CoA Is Dehydrogenated to 3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholest-24-Enoyl-CoA (THCA-CoA)

25(S) DHCA-CoA Is Dehydrogenated to 25(S) 3alpha,7alpha-Dihydroxy-5beta-Cholest-24-Enoyl-CoA

3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholest-24-Enoyl-CoA (THCA-CoA) Is Hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-Cholestanoyl-CoA

25(S) 3alpha,7alpha-Dihydroxy-5beta-Cholest-24-Enoyl-CoA Is Hydrated to (24R, 25R) 3alpha,7alpha,24-Trihydroxy-5beta-Cholestanoyl-CoA

(24R, 25R) 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-Cholestanoyl-CoA Is Oxidized to 3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholest-24-One-CoA

(24R, 25R) 3alpha,7alpha,24-Trihydroxy-5beta-Cholestanoyl-CoA Is Oxidized to 3alpha,7alpha-Dihydroxy-5beta-Cholest-24-One-CoA

Thiolysis of 3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholan-24-One-CoA Yields Choloyl-CoA (3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholan-24-One-CoA) and Propionyl CoA

Thiolysis of 3alpha,7alpha-Dihydroxy-5beta-Cholan-24-One-CoA Yields Chenodeoxycholoyl-CoA (3alpha,7alpha-Dihydroxy-5beta-Cholan-24-One-CoA) and Propionyl CoA

Hydrolysis of Choloyl-CoA to Cholate and CoASH

Cholate Is Translocated From the Peroxisomal Matrix to the Cytosol

Choloyl CoA Reacts with Glycine or Taurine to Form Glycocholate or Taurocholate

Chenodeoxycholoyl CoA Reacts with Glycine or Taurine to Form Glycochenodeoxycholate or Taurochenodeoxycholate

Bile Salts Are Translocated From the Peroxisomal Matrix to the Cytosol

ABCB11 Transports Bile Salts From Cytosol to Extracellular Region

Exact Match

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