Glycosphingolipid Metabolism

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1660662).

Glycosphingolipid Metabolism - Ontify

Glycosphingolipid Metabolism

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1660662).

Statements about Glycosphingolipid Metabolism

Wikidata

Statements about Glycosphingolipid Metabolism

Wikidata

Instance Of

Biological Pathway

Glycosphingolipid Metabolic Process

Part Of

Sphingolipid Metabolism

Has Part(s)

32 items

Beta-Galactosidase Hydrolyses GM1 to GM2

Neu5Ac Is Cleaved From GM3 by NEU1 and 4 to Form a Globoside (Lysosomal Lumen)

Beta-Galactosidase Can Also Hydrolyse Globosides to Form Cerebrosides

Exact Match

https://identifiers.org/reactome:R-H ...

Hexosaminidase A Cleaves GalNAc From GM2 to Form GM3

Ganglioside GM2 Activator Presents GM2 to Hexosaminidase for Cleavage

Arylsulfatase A Hydrolyses Sulfate From Sulfatide to Form Cerebroside

CERK Phosphorylates CERA to Form C1P

UGT8 Transfers Gal From UDP-Gal to CERA

Ectonucleotide Pyrophosphatase/Phosphodiesterase 7 (ENPP7) Hydrolyses Sphingomyelin

Ceramide Glucosyltransferase (UGCG) Catalyses the Transfer of Glucose to Ceramide

Acid Ceramidase Hydrolyses Ceramide Into Sphingosine and Free Fatty Acid (Lysosome)

SUMF1 Mediates the Oxidation of Cysteine to Formylglycine, Producing Active Arylsulfatases

Neutral Ceramidase Hydrolyses Ceramide Into Sphingosine and Free Fatty Acid (Plasma Membrane)

B3GALNT1 Transfer GalNAc to Gb3Cer to Form Gb4Cer

Both Hexosaminidase A and B Can Cleave GalNAc From Globoside

SUMF2 Binds SUMF1, Inhibiting SUMF1-Mediated Activation of Arylsulfatases

Active ARSA Translocates to the Lysosome

Glucosylceramidase 3 Cleaves the Glucosidic Bond of Glucocerebroside to Form Ceramide (Cytosol)

Neu5Ac Is Cleaved From GM3 by NEU3 to Form Globoside (Plasma Membrane)

Steryl Sulfatase Hydrolyses Sulfate From Steroid Sulfates

Sphingomyelin Phosphodiesterase 4 (SMPD4) Hydrolyses Sphingomyelin to Ceramide (ER Membrane)

B4GALNT1 Dimer Transfers GalNAc From UDP-GalNAc to GM3 and GD3 Gangliosides

Glucosylceramidase Cleaves the Glucosidic Bond of Glucocerebroside to Form Ceramide

Galactocerebrosidase Cleaves the Galactosyl Bond of Galactocerebroside to Form Ceramide

Sphingomyelin Phosphodiesterase 2 and 3 (SMPD2 and 3) Hydrolyse Sphingomyelin to Ceramide (Plasma Membrane)

ESYT1:ESYT2:ESYT3 Transport GPL From Plasma Membrane to ER Membrane

Neu5Ac Is Cleaved From GM3 by NEU2 to Form a Globoside (Cytosol)

Sphingomyelin Phosphodiesterase (SMPD1) Hydrolyses Sphingomyelin to Ceramide (Lysosome)

Alpha-Galactosidase A Removes a Terminal Galactose From Alpha-D-Galactoside Oligomers

Glucosylceramidase 2 Cleaves the Glucosidic Bond of Glucocerebroside to Form Ceramide (Plasma Membrane)

GLTP Transports GSL From Plasma Membrane to ER Membrane

GLTPD1 Transports C1P From Plasma Membrane to Golgi Membrane