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Sphingolipid De Novo Biosynthesis - Ontify
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Sphingolipid De Novo Biosynthesis
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1660661).
Statements about
Sphingolipid De Novo Biosynthesis
Instance Of
Biological Pathway
Sphingolipid Biosynthetic Process
Part Of
Sphingolipid Metabolism
Has Part(s)
33 items
ALDH3B1 Oxidises HXAL to PALM
Exact Match
https://identifiers.org/reactome:R-H ...
3-Ketosphinganine + NADPH + H+ => Sphinganine + NADP+
Ceramide + H2O => Stearate + Sphingosine [Golgi]
CERT1-2 Releases Its Bound Ceramide Into the Membrane of the Golgi Apparatus
Phosphatidylcholine + Ceramide <=> Sphingomyelin + Diacylglycerol [SGMS1]
SPHK1 Phosphorylates SPG to S1P
PRKD1,2,3 Phosphorylates CERT1-2
CERT1-2 Binds Ceramide
Phosphatidylcholine + Ceramide <=> Sphingomyelin + Diacylglycerol [SGMS2]
FA2H Hydroxylates CERA
Phytoceramide + H2O => Stearate + Phytosphingosine
Sphingosine 1-Phosphate + H2O => Sphingosine + Orthophosphate [Extracellular]
Monophospho-CERT + 2 ATP => Multiphospho-CERT + 2 ADP
Ceramide + H2O <=> Stearate + Sphingosine [Endoplasmic Reticulum]
ALDH3B2 Oxidises HXAL to PALM
ALDH3A2-1 Oxidises HD2NAL to PALM
Sphinganine 1-Phosphate + H2O => Sphinganine + Orthophosphate
Sphingosine 1-Phosphate + H2O => Sphingosine + Orthophosphate [Cytosolic - SGPP]
Sphinganine + Stearyl-CoA => Dihydroceramide + CoASH
Sphingosine 1-Phosphate + H2O => Sphingosine + Orthophosphate [Cytosolic - PPAP]
Sphingosine 1-Phosphate => Phosphoethanolamine + Hexadec-2-Enal
SPHK2 Phosphorylates SPG to S1P
SPNS2 Transports S1P From Cytosol to Extracellular Region
SPHK2 Binds SPHK2 Inhibitors
Dihydroceramide + NAD(P)H + H+ + O2 => Ceramide + NAD(P)+ + H2O
Multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 Orthophosphate
Sphinganine (Dihydrosphingosine) +ATP => Sphinganine 1-Phosphate + ADP
Palmitoyl-CoA + Serine => 3-Ketosphinganine + CoASH + CO2
Sphinganine 1-Phosphate => Phosphoethanolamine + Hexadecanal
Multiphospho-CERT + PPM1L:VAPA/B => Multiphospho-CERT:PPM1L:VAPA/B
CERT1-2 Dissociates From the Endoplasmic Reticulum
Dihydroceramide + NADPH + H+ + O2 => Phytoceramide + NADP+ + H2O
SAMD8 Transforms PE and CERA to CPE
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