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Synthesis of PIPs at the Plasma Membrane - Ontify

Synthesis of PIPs at the Plasma Membrane

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1660499).

Statements about Synthesis of PIPs at the Plasma Membrane

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Instance Of

Biological Pathway

Phosphatidylinositol Biosynthetic Process

Part Of

Has Part(s)

33 items

PTEN Dephosphorylates PIP3

PI4P Is Phosphorylated to PI(4,5)P2 by PIP5K1A-C at the Plasma Membrane

PI5P Is Phosphorylated to PI(4,5)P2 by PIP4K2 Dimers at the Plasma Membrane

Exact Match

https://identifiers.org/reactome:R-H ...

PI(4,5)P2 Is Dephosphorylated to PI4P by SYNJ/INPP5[1] at the Plasma Membrane

PI3P Is Dephosphorylated to PI by the MTMR2:SBF2 Tetramer at the Plasma Membrane

PI(4,5)P2 Is Phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the Plasma Membrane

MTMR8 Binds MTMR9

PI(3,4,5)P3 Is Dephosphorylated to PI(3,4)P2 by INPP5[2] at the Plasma Membrane

MTMR2 Dimerizes

PI3P Is Phosphorylated to PI(3,5)P2 by PIP5K1A/B at the Plasma Membrane

PI3P Is Dephosphorylated to PI by SYNJ/MTMs at the Plasma Membrane

PLEKHA3,8 Bind PI4P, ARF1

PI4P Is Phosphorylated to PI(3,4)P2 by PI3K3C[2] at the Plasma Membrane

PLEKHA4,(5,6) Bind PI3P

PI(3,5)P2 Is Dephosphorylated to PI5P by the MTMR2:SBF2 Tetramer at the Plasma Membrane

PI Is Phosphorylated to PI5P by PIP5K1A/B at the Plasma Membrane

BMX Phosphorylates RUFY1

MTMR6 Binds MTMR9

PI3P Is Phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the Plasma Membrane

PTPN13:PLEKHA1,2 Bind PI(3,4)P2

PI(3,4)P2 Is Phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the Plasma Membrane

PI3P Is Dephosphorylated to PI by MTMR9-Bound MTMR8 or MTMR6 at the Plasma Membrane

PI(3,5)P2 Is Dephosphorylated to PI5P by MTMR9-Bound MTMR6 or MTMR8 at the Plasma Membrane

P-Y281,292-RUFY1 Binds RAB4A:GTP, RAB5:GTP, RAB14:GTP

PI(3,5)P2 Is Dephosphorylated to PI3P by SYNJ at the Plasma Membrane

MTMR2 Binds SBF2

PI(3,5)P2 Is Dephosphorylated to PI5P by SYNJ/MTMs at the Plasma Membrane

PI(3,4)P2 Is Dephosphorylated to PI3P by INPP4A/B at the Plasma Membrane

P-Y281,292-RUFY1 Binds PI3P

PI Is Phosphorylated to PI4P by PI4K2A/B at the Plasma Membrane

P-Y281,292-RUFY1 Translocates From Cytosol to Early Endosome Membrane

PI4P Is Dephosphorylated to PI by SYNJ at the Plasma Membrane

PI(3,4)P2 Is Dephosphorylated to PI4P by PTEN at the Plasma Membrane