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Synthesis of Leukotrienes (LT) and Eoxins (EX)
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2142691).
Statements about
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Instance Of
Biological Pathway
Leukotriene Metabolic Process
Part Of
Arachidonic Acid Metabolism
Has Part(s)
20 items
Arachidonic Acid Is Oxidised to 5S-HpETE by ALOX5
CYP4F2, 4F3 20-Hydroxylate LTB4
GGT1, 5 Dimers Hydrolyse LTC4 to LTD4
LTD4 Is Converted to LTE4 by DPEP1/2
Exact Match
https://identifiers.org/reactome:R-H ...
LTC4 Is Exported From the Cytosol by ABCC1
ALOX5 Is Phosphorylated by MAPKAP2
5S-HpETE Is Dehydrated to LTA4 by ALOX5
LTA4 Is Converted to EXA4 by ALOX15
20cooh-LTB4 Is Converted to 18cooh-LTB4
20oh-LTB4 Is Oxidised to 20cho-LTB4 by CYP4F2/4F3
20cho-LTB4 Is Oxidised to 20cooh-LTB4 by CYP4F2/4F3
LTB4 Is Oxidised to 12-oxoLTB4 by PTGR1
20cho-LTB4 Is Oxidised to 20cooh-LTB4 by ALDH
LTA4 Is Converted to LTC4 by LTC4S
LTA4 Is Hydrolysed to 6t-/6t,12epi-LTB4
EXA4 Is Converted to EXC4 by LTC4S
EXD4 Is Converted to EXE4 by DPEP
ALOX5 Binds ALOX5 Inhibitors
EXC4 Is Converted to EXD4 by GGT
LTA4 Is Hydolysed to LTB4 by LTA4H
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