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Growth Hormone Receptor Signaling - Ontify

Growth Hormone Receptor Signaling

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-982772).

Statements about Growth Hormone Receptor Signaling

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Instance Of

Biological Pathway

Growth Hormone Receptor Signaling Pathway via JAK-STAT

Part Of

Cytokine Signaling in Immune System

Has Part(s)

28 items

P-STAT5 Dimerizes

STAT5 Dimers Translocate to the Nucleus

Growth Hormone Forms Dimers and Oligomers

Growth Hormone Receptor Binds JAK2

Growth Hormone Receptor Dimerizes

Growth Hormone Binds the Growth Hormone Receptor

GH:GHR:JAK2 Complex Undergoes a Conformational Change

JAK2 Phosphorylation

JAK2 Phosphorylation of IRS-1/2

JAK2 Phosphorylation of GHR

STAT5 Association with GHR

STAT5 Tyrosine Phosphorylation

P-STAT5A/B Dissociates From the Growth Hormone Receptor

Growth Hormone Receptor Binds Lyn

Lyn Activates ERK

JAK2 Phosphorylates STAT1/STAT3

JAK2 Binds STAT1/3

SOCS Binding to GHR

SOCS Binding to JAK2

PTP1B Binds the GH Receptor Complex

PTP1B Dephosphorylates GHR

PTP1B Dephosphorylates JAK2

SHP1 (PTPN6) Binds JAK2 in the Receptor Complex

SHP1 (PTPN6) Dephosphorylates JAK2

Metalloprotease Cleavage of GHR

GHR Internalization

Exact Match

https://identifiers.org/reactome:R-H ...