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Interleukin-35 Signalling - Ontify
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Interleukin-35 Signalling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8984722).
Statements about
Interleukin-35 Signalling
Instance Of
Biological Pathway
Interleukin-35-Mediated Signaling Pathway
Part Of
Interleukin-12 Family Signaling
Has Part(s)
26 items
EBI3:CANX Binds IL12A
CANX Dissociates From IL12A:EBI3
Interleukin-35 Translocates From the ER Lumen to the Extracellular Region
IL35 Binds IL27RA:IL12RB2 Receptor
JAK1,JAK2 Bound to IL27RA:IL12RB2 Receptor Are Phosphorylated
STAT1,STAT3 Associate with IL27RA:IL12RB2 Receptor
JAK1,JAK2 Bound to IL27RA:IL12RB2 Receptor Phosphorylate STAT1,STAT3
P-STAT1, P-STAT3 Dissociate From IL27RA:IL12RB2 Receptor
IL35 Binds IL12RB2:IL12RB2 Receptor
JAK2 in IL12RB2:IL12RB2 Receptor Is Phosphorylated
STAT4 Binds IL12RB2:IL12RB2
IL35 Binds IL6ST:IL6ST Receptor
JAK1/JAK2/TYK2 Bound to IL6ST:IL6ST Are Phosphorylated
JAK2 Bound to IL12RB2:IL12RB2 Phosphorylate STAT4
P-STAT4 Dissociates From IL12RB2:IL12RB2 Receptor
JAK1/JAK2/TYK2 Bound to IL6ST:IL6ST Phosphorylate STAT1
STAT1 Associates with IL6ST:IL6ST
P-STAT1 Dissociates From IL6ST:IL6ST
IL35 Binds IL-12RB2:IL6ST Receptor
JAK1/JAK2 Bound to IL35:IL6ST:IL12RB2 Receptor Are Phosphorylated
STAT1 and STAT4 Associate with IL12RB2:IL6ST Receptor
JAK1/JAK2 Bound to IL12RB2:IL6ST Receptor Phosphorylates STAT1 and STAT4
P-STAT1 and P-STAT4 Dissociate From IL12RB2:IL6ST Receptor
P-STAT1:p-STAT4 Translocates to the Nucleus
EBI3 Gene Transcription and Translation
IL12A Gene Transcription and Translation
Exact Match
https://identifiers.org/reactome:R-H ...
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