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Interleukin-10 Signaling - Ontify

Interleukin-10 Signaling

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6783783).

Statements about Interleukin-10 Signaling

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Instance Of

Biological Pathway

Cytokine-Mediated Signaling Pathway

Part Of

Signaling by Interleukins

Has Part(s)

15 items

Expression of PTGS2

IL10 Dimer Binds IL10RA:JAK1

IL10 Dimer:2xIL10RA1:JAK1 Binds IL10RB:TYK2

JAK1,TYK2 Phosphorylate JAK1,TYK2

P-Y-JAK1,p-Y-TYK2 Phosphorylate IL10RA

IL10 Dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 Binds STAT3

STAT3 Is Phosphorylated by P-Y-JAK1,P-Y-TYK2

P-Y705-STAT3 Dissociates From IL10 Dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3

P-Y705-STAT3 Dimerizes

IL10 Negatively Regulates Extracellular Inflammatory Mediators

IL10 Negatively Regulates Plasma Membrane-Associated Inflammatory Mediators

IL10 Positively Regulates Extracellular Inflammatory Mediators

IL10 Positively Regulates Plasma Membrane-Associated Inflammatory Mediators

P-Y705-STAT3 Dimer Translocates From Cytosol to Nucleoplasm

Exact Match

https://identifiers.org/reactome:R-H ...