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Interleukin-7 Signaling - Ontify
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Interleukin-7 Signaling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1266695).
Statements about
Interleukin-7 Signaling
Instance Of
Biological Pathway
Interleukin-7-Mediated Signaling Pathway
Part Of
Signaling by Interleukins
Has Part(s)
26 items
BRWD1 Binds SMARCA4
BRWD1 Binds AcK(9,14,18,79)-P(S10,T11)-Histone H3
IL2RG Binds JAK3
P-STAT5 Dimerizes
STAT5 Dimers Translocate to the Nucleus
IL7 Binds HGF(495-728) to Form PPBSF
IL7 Binds IL7R:JAK1
JAK1 Binds IL7R
IL7:IL7R:JAK1 Binds IL2RG:JAK3
IL7R Is Phosphorylated on Y499
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 Binds PI3K Regulatory Subunits
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-Regulatory Subunits Binds IRS1,IRS2
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 Is Phosphorylated
P-STAT5A, P-STAT5B Dissociate From IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B Phosphorylates STAT5
Expression of STAT5 Upregulated Genes
P-STAT5 Dimers Bind the BRWD1 Gene Promoter
BRWD1 Gene Expression Is Repressed by STAT5
RAG1:RAG2 Recombinase Binds Immunoglobulin Kappa Locus in a BRWD1-Dependent Manner
TSLP Binds CRLF2:IL7R
STAT3 Binds TSLP:IL7R:CRLF2
STAT3 Is Phosphorylated by TSLP:IL7R:CRLF2:STAT3 Complex
P-STAT3 Dissociates From TSLP:IL7R:CRLF2:p-STAT3 Complex
P-STAT5 Binds CISH, SOCS1 and SOCS2 Gene
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 Binds STAT5
JAK3 Binds JAK3 Inhibitors
Exact Match
https://identifiers.org/reactome:R-H ...
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