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Interleukin-4 and Interleukin-13 Signaling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6785807).
Statements about
Interleukin-4 and Interleukin-13 Signaling
Instance Of
Biological Pathway
Cytokine-Mediated Signaling Pathway
Part Of
Signaling by Interleukins
Has Part(s)
47 items
Expression of IL18, ALOX5
IL2RG Binds JAK3
IL4R Binds JAK2
IL13RA1 Binds TYK2
IL4 Binds IL4R:JAK2
IL4:IL4R:JAK2 Binds IL13RA1:TYK2
P-Y705-STAT3,p-Y641-STAT6 Dissociate
P-Y705-STAT3, P-Y641-STAT6 Dimerise
P-Y705-STAT3 Dimer, P-Y641-STAT6 Dimer Translocate to Nucleus
Expression of STAT3-Upregulated Cytosolic Proteins
Expression of NDN,TP53
Exact Match
https://identifiers.org/reactome:R-H ...
IL4:IL4R:JAK2 Binds IL2RG:JAK3
JAK1 Binds IL4R in IL4-Bound IL4R1
Expression of GATA3
STAT3,STAT6 Bind P-Y-IL4R
IL4R, IL2RG, JAK1 in IL4-Bound IL4R1:JAK1 Are Phosphorylated
Expression of BCL2, BCL2L1
Expression of STAT6-Upregulated Plasma Membrane Proteins
Expression of SOCS1
Expression of STAT6-Upregulated Extracellular Proteins
Expression of IL13-Upregulated Plasma Membrane Proteins
Expression of CD36
Expression of PTGS2
Expression of STAT3-Upregulated Extracellular Proteins
JAK1 Phosphorylates STAT3,STAT6
Expression of HSP90B1
Expression of STAT3-Upregulated Plasma Membrane Proteins
SOCS5,(SOCS1) Bind IL4RA
JAK1 Binds IL4R in IL13-Bound IL13R Type II
IL13 Binds IL13RA2
JAK3 Binds JAK3 Inhibitors
STAT1,STAT3,STAT6 Phosphorylation
IL13:IL13RA:TYK2 Binds IL4R:JAK2
P-Y-STATs Dissociate
Expression of FASLG
Expression of IL13-Downregulated Extracellular Proteins
Expression of STAT3-Upregulated Nuclear Proteins
P-Y-STATs Dimerize
Expression of HSPA8, ALOX15
Expression of HMOX1
Expression of IL4, IL13-Upregulated Extracellular Proteins
STAT1,STAT3,STAT6 Bind IL13:IL13R Type II
IL4R, IL13RA, JAK2 and TYK2 Are Tyrosine Phosphorylated
P-Y-STATs Translocate to Nucleus
IL13 Binds IL13RA:TYK2
Expression of MAOA
Expression of IL4,IL13-Downregulated Extracellular Genes
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