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Interleukin-3, Interleukin-5 and GM-CSF Signaling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-512988).
Statements about
Interleukin-3, Interleukin-5 and GM-CSF Signaling
Instance Of
Biological Pathway
Cytokine-Mediated Signaling Pathway
Has Part(s)
27 items
Interleukin Receptor SHC Signaling
Regulation of Signaling by CBL
P-STAT5 Dimerizes
STAT5 Dimers Translocate to the Nucleus
The Common Beta Chain IL3RB Binds JAK2
GM-CSF Receptor Alpha Subunit Binds GM-CSF
GM-CSF Receptor Alpha:GM-CSF Binds Bc
Interleukin-5 Is a Homodimer
Interleukin-5 Receptor Alpha Subunit Binds Interleukin-5
Interleukin-5:Interleukin-5 Receptor Alpha Binds IL3RB:JAK2
Interleukin-3 Receptor Alpha Subunit Binds Interleukin-3
Interleukin-3 Receptor Alpha: Interleukin-3 Binds IL3RB:JAK2
The Receptor Is Activated
JAK2 Is Phosphorylated, Activated
STAT5 Is Recruited by JAK2
Activation of STAT5a/B by JAK2
P-STAT5 Dissociates From the Receptor Complex
Tyrosine Kinases Phosphorylate the Receptor
Recruitment of SHC1 Is Mediated by Y593 of the Common Beta Chain
SHC1 Bound to the Common Beta Chain Becomes Tyrosine Phosphorylated
IL3 Stimulation Induces Vav Binding to Tec Kinase
SHP1 and SHP2 Bind the Common Beta Chain
SHP1 and SHP2 Dephosphorylate Y628 of IL3RB
SHP2 Can Recruit GRB2
IL3RB Is Phosphorylated on Ser-585
P-S585-IL3RB Binds 14-3-3 Proteins
14-3-3 Zeta Binding Allows Recruitment of PI3K
Part Of
Signaling by Interleukins
Exact Match
https://identifiers.org/reactome:R-H ...
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