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Interferon Gamma Signaling - Ontify

Interferon Gamma Signaling

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-877300).

Statements about Interferon Gamma Signaling

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Instance Of

Biological Pathway

Interferon-Gamma-Mediated Signaling Pathway

Has Part(s)

15 items

Regulation of IFNG Signaling

IFNG Dimer Binds IFNGR

Phosphorylation of JAK2

Transphosphorylation of JAK1

Phosphorylation of IFNGR1 by JAK Kinases

Binding of STAT1 to P-IFNGR1

Phosphorylation of STAT1 by JAK Kinases

Phosphorylation of STAT1 at Ser727

Release of STAT1 Dimer From Active Receptor Unit

Translocation of STAT1 Dimer to Nucleus

GAF Binds the GAS Promoter Elements in the IFNG-Regulated Genes

Expression of IFNG-Stimulated Genes

IFNGR1:JAK1:INFGR2:JAK2 Binds JAK1,2 Inhibitors

STAT1 Stimulates SMAD7 Gene Transcription

IFNG Dimer Binds IFNG Inhibitors

Part Of

Interferon Signaling

Exact Match

https://identifiers.org/reactome:R-H ...