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Interferon Alpha/Beta Signaling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-909733).
Statements about
Interferon Alpha/Beta Signaling
Instance Of
Biological Pathway
Has Part(s)
21 items
Activation of JAK Kinases
ISGF3 Binds the ISRE Promoter Elements in IFN-Stimulated Genes
Part Of
Exact Match
https://identifiers.org/reactome:R-H ...
Type I Interferon Signaling Pathway
Recruitment of STAT2 to P-IFNAR1
Phosphorylation of STAT1
P-STAT1dimer:KPNA1 Binds KPNB1
Interaction of IRF9 with P-STAT2:p-STAT1
Phosphorylation of INFAR1 by TYK2
Formation of P-STAT1 Homodimer
IFNAR1:TYK2 Binds TYK2 Inhibitors
Regulation of IFNA/IFNB Signaling
IFN Alpha/Beta Binds to IFNAR2
Recruitment of IFNAR1
Release of P-STAT2:p-STAT1 Dimer
Expression of IFN-Induced Genes
Phosphorylation of STAT2
Translocation of ISGF3 Complex to Nucleus
P-STAT1 Dimer Binds KPNA1
ABCE1 Binds RNASEL, Inhibiting It
Translocation of P-STAT1:p-STAT1 Dimer to Nucleus
IFNAR2:JAK1:STAT2 Binds JAK1,2 Inhibitors
IFNAR2:JAK1:STAT2 Binds Type 1 Interferon Analogs
Interferon Signaling
