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The NLRP3 Inflammasome - Ontify
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The NLRP3 Inflammasome
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-844456).
Statements about
The NLRP3 Inflammasome
Instance Of
Biological Pathway
Part Of
Inflammasomes
Has Part(s)
18 items
SGT1:HSP90 Binds Inactive NLRP3
SGT1 Binds HSP90
P2X7 Forms Oligomeric Non-Selective Cation Channels
ATP Binds to P2X7
P2X7 Mediates Loss of Intracellular K+
P2X7 Mediates Membrane Pores that Include Pannexin-1
TXNIP Is Released From Oxidized Thioredoxin
TXNIP Binds Reduced Thioredoxin
TXNIP Binds NLRP3
ROS Oxidize Thioredoxin
NLRP3 Oligomerizes via NACHT Domains
NLRP3 Activation by Small Molecules
NLRP3 Activation by Elicitor Proteins
NLRP3 Recruits PYCARD (ASC) via a PYD-PYD Interaction
PYCARD Recruits Procaspase-1 via CARD
PSTPIP1 Binds Pyrin
Pyrin Binds ASC
Expression of NLRP3 Gene
Exact Match
https://identifiers.org/reactome:R-H ...
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