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TRAF6-Mediated Induction of TAK1 Complex Within TLR4 Complex - Ontify

TRAF6-Mediated Induction of TAK1 Complex Within TLR4 Complex

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-937072).

Statements about TRAF6-Mediated Induction of TAK1 Complex Within TLR4 Complex

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Instance Of

Biological Pathway

I-kappaB Kinase/NF-kappaB Signaling

Part Of

TRIF(TICAM1)-Mediated TLR4 Signaling

Has Part(s)

Activated TRAF6 Synthesizes Unanchored Polyubiquitin Chains upon TLR Stimulation

Activated TLR4:TICAM1 Recruits TRAF6

Auto Ubiquitination of TRAF6 Bound to the Activated TLR4 Complex

Activated TLR4:TICAM1:K63pUb-TRAF6 Recruits TAK1complex

Activation of TAK1 Complex Bound to Activated TLR4 Complex

Phosphorylated TAK1 Leaves Activated TLR Receptor Complex

Exact Match

https://identifiers.org/reactome:R-H ...