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TICAM1,TRAF6-Dependent Induction of TAK1 Complex - Ontify

TICAM1,TRAF6-Dependent Induction of TAK1 Complex

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9014325).

Statements about TICAM1,TRAF6-Dependent Induction of TAK1 Complex

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Instance Of

Biological Pathway

I-kappaB Kinase/NF-kappaB Signaling

Part Of

Toll Like Receptor 3 (TLR3) Cascade

Has Part(s)

Viral dsRNA:TLR3:TICAM1 Complex Recruits TRAF6

Auto Ubiqitination of TRAF6 Bound to Viral dsRNS:TLR3:TICAM1 Complex

Activated TLR3:TRIF:K63pUb-TRAF6 Recruits TAK1complex

Activation of Recruited TAK1 Within the Activated TLR3 Complex

Phosphorylated TAK1 Dissociates From the TLR3 Receptor Complex

Activated TRAF6 Synthesizes Unanchored Polyubiquitin Chains upon TLR3 Stimulation

Exact Match

https://identifiers.org/reactome:R-H ...