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TICAM1-Dependent Activation of IRF3/IRF7
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9013973).
Statements about
TICAM1-Dependent Activation of IRF3/IRF7
Instance Of
Biological Pathway
TRIF-Dependent Toll-Like Receptor Signaling Pathway
Part Of
Toll Like Receptor 3 (TLR3) Cascade
Has Part(s)
Auto-Ubiquitination of TRAF3 Within Activated TLR3 Complex
TANK Is Ubiquitinated Within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA
Recruitment of TBK1/IKK Epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 Followed by Their Phosphorylation
IRF3/IRF7 Recruitment to P-TBK1/P-IKK Epsilon Bound to the Activated TLR3
Phosphorylation of IRF-3/IRF7 and Their Release From the Activated TLR3 Complex
Dimerization of Phosphorylated IRF3/IRF7
Dimerized Phospho-IRF3/IRF7 Is Transported to the Nucleus
Exact Match
https://identifiers.org/reactome:R-H ...
TRAF3 Binds to TRIF:activated TLR3 Complex
TANK Binds K63-Poly-Ub-TRAF3:TICAM1:activated TLR3
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