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MHC Class II Antigen Presentation - Ontify

MHC Class II Antigen Presentation

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2132295).

Statements about MHC Class II Antigen Presentation

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Instance Of

Biological Pathway

Antigen Processing and Presentation of Exogenous Peptide Antigen via MHC Class II

Part Of

Adaptive Immune System

Has Part(s)

27 items

Formation of MHC II Alpha Beta Heterodimer

Interaction of Invariant Chain Trimer and MHC II Alpha Beta Dimer

Formation of Nonameric Complex

Dissociation of CANX From Nonameric Complex

Formation of COPII Vesicle

Fusion of COPII Vesicle with Golgi Complex

Transport of MHC II:Ii Complex Along Golgi to TGN

TGN-Lysosomal Vesicle Coat Assembly

Dissociation of Arf1:GDP, AP-1 Clathrin Coated Nonameric Complex

Translocation of TGN-Lysosome Vesicle to Lysosome

TGN-Lysosome Vesicle Uncoating and Release of Nonameric Complex to Lysosome

Transport of MHC II:Ii Complex to Plasma Membrane

Insertion of MHC II:Ii Complex in to the Plasma Membrane

Recruitment of Clathrin Coated Vesicle by Ii

Internalization of MHC II:Ii Clathrin Coated Vesicle

Uncoating of Clathrin-Coated Vesicles and Fusion with Endosomes

Trafficking of Nonameric Complex in the Endocytic Pathway

Initial Proteolyis of Ii by Aspartic Proteases to Lip22

Cleavage of Lip22 to Lip10

Generation of CLIP From Lip10

Disassociation of CLIP From MHC II

MHC Class II Antigen Internalization

Reduction of Disulphide Bonds in MHC II Antigens

MHC Class II Antigen Processing

Loading of Antigenic Peptides

Transport of Antigen Loaded MHC II Molecules to Surface

LAG3 (CD233) Binds MHC II

Exact Match

https://identifiers.org/reactome:R-H ...