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Antigen Processing: Ubiquitination & Proteasome Degradation - Ontify

Antigen Processing: Ubiquitination & Proteasome Degradation

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-983168).

Statements about Antigen Processing: Ubiquitination & Proteasome Degradation

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Instance Of

Biological Pathway

Protein Polyubiquitination

Part Of

Class I MHC Mediated Antigen Processing & Presentation

Has Part(s)

E1 Mediated Ubiquitin Activation

Transfer of Ubiquitin From E1 to E2

Interaction of E3 with Substrate and E2-Ub Complex

Transfer of Ub From E2 to Substrate and Release of E2

Polyubiquitination of Substrate

Release of E3 From Polyubiquitinated Substrate

Proteasomal Cleavage of Substrate

Trimming of N-Ter Extended Precursor Fragments by Cytosolic Aminopeptidases

THOP1 Cleaves Oligopeptide Fragment (8-16aa)

Exact Match

https://identifiers.org/reactome:R-H ...