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Antigen Activates B Cell Receptor (BCR) Leading to Generation of Second Messengers - Ontify

Antigen Activates B Cell Receptor (BCR) Leading to Generation of Second Messengers

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-983695).

Statements about Antigen Activates B Cell Receptor (BCR) Leading to Generation of Second Messengers

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Instance Of

Biological Pathway

Has Part(s)

26 items

Calcium Binds Calmodulin

STIM1 Activation of CRAC

CRAC Translocates Calcium From the Extracellular Region to the Cytosol

IP3 Binds to the IP3 Receptor, Opening the Endoplasmic Reticulum Ca2+ Channel

IP3R:I(1,4,5)P3 Tetramer Transports Ca2+ From ER Lumen to Cytosol

STIM1 Oligomerizes

STIM1 Binds TRPC1 Forming STIM1:TRPC1 Complex

TRPC1 Translocates Calcium From the Extracellular Region to the Cytosol

Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) Binds BTK, PLCG2, VAV1, NCK1

P-SYK and LYN Phosphorylate BTK

BTK Binds BTK Inhibitors

Part Of

Signaling by the B Cell Receptor (BCR)

Exact Match

https://identifiers.org/reactome:R-H ...

BCAP Signalosome Phosphorylates PI(4,5)P2 Forming PI(3,4,5)P3

P-6Y-SYK Phosphorylates BLNK (SLP65)

LYN, FYN, BLK Phosphorylate ITAMs of Ig-Alpha (CD79A) and Ig-Beta (CD79B)

BTK Autophosphorylates

SYK Autophosphorylates at the Activated BCR

BLNK (SLP-65) Signalosome Hydrolyzes Phosphatidyinositol Bisphosphate Forming Diacylglycerol and Inositol-1,4,5-Trisphosphate

SYK Binds the Activated BCR

P-DAPP1 (P-BAM32) Binds PLCG2

Phosphorylated BTK Phosphorylates PLCG2

CD19 Signalosome Phosphorylates PI(4,5)P2 Forming PI(3,4,5)P3

CD19 Is Phosphorylated

The Immunoglobulin of the BCR Binds Antigen

P-PIK3AP1 (P-BCAP) Binds PIK3CD:PIK3R1 (PI3K Delta)

P-CD19:VAV Binds PI3K and GRB2

PI(3,4,5)P3 (PIP3) Binds DAPP1 (BAM32) and DAPP1 Is Phosphorylated