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Common Pathway of Fibrin Clot Formation - Ontify
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Common Pathway of Fibrin Clot Formation
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-140875).
Statements about
Common Pathway of Fibrin Clot Formation
Instance Of
Biological Pathway
Blood Coagulation
Part Of
Formation of Fibrin Clot (Clotting Cascade)
Has Part(s)
29 items
Prothrombin -> Activated Thrombin (Factor IIa) + Thrombin Activation Peptide (Xa Catalyst)
Factor V -> Factor Va + Factor V Activation Peptide
Prothrombin -> Activated Thrombin (Factor IIa) + Thrombin Activation Peptide (Prothrombinase Catalyst)
Factor Va + Factor Xa -> Va:Xa Complex (Prothrombinase)
Fibrinogen -> Fibrin Monomer + 2 Fibrinopeptide A + 2 Fibrinopeptide B
N Fibrin Monomers -> Fibrin Multimer
Factor XIII -> Factor XIII Cleaved Tetramer + 2 Factor XIII A Activation Peptides
Fibrin Multimer -> Fibrin Multimer, Crosslinked + NH4+
SERPINC1 Binds SERPINC1 Activators
Activated Thrombin (Factor IIa) + Antithrombin III:heparin -> Thrombin:antithrombin III:heparin
Thrombin:antithrombin III:heparin -> Thrombin:cleaved Antithrombin III:heparin
Thrombin:cleaved SERPINC1:SERPINC1 Activators -> Thrombin:cleaved SERPINC1 + SERPINC1 Activators
Activated Thrombin (Factor IIa) + Thrombomodulin -> Activated Thrombin:thrombomodulin
PROCR Binds Protein C
Activated Thrombin:thrombomodulin Cleaves PROCR:Protein C to PROCR:Activated Protein C
Activated Protein C Is Released From PROCR
Activated Protein C Binds Protein S
Activated Protein C Cleaves Factor Va to Factor Vi Intermediate Form
Activated Protein C Cleaves Factor Va Intermediate Form for Factor Va
Activated Protein C Cleaves Factor VIIIa
Heparin Cofactor 2 (SERPIND1) Binds Activated Thrombin (Factor IIa)
Protease Nexin-1 (PN1) Is a Specific and Extremely Efficient Inhibitor of Thrombin.
SERPINA5 Binds Activated Protein C
Activated Protein C:PROCR Binds F2R
Soluble PROCR Binds Activated Protein C
Factor Xa Inhibitors Binds Xa
Factor Xa Inhibitors Bind Va:Xa
Exact Match
https://identifiers.org/reactome:R-H ...
Factor XIII Cleaved Tetramer + 2 Ca++ -> Factor XIIIa + 2 Factor XIII B Chain
Soluble PROCR Binds PRTN3:CD177
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