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GPVI-Mediated Activation Cascade - Ontify

GPVI-Mediated Activation Cascade

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-114604).

Statements about GPVI-Mediated Activation Cascade

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Instance Of

Biological Pathway

Part Of

Platelet Activation, Signaling and Aggregation

Has Part(s)

25 items

Fyn/Lyn-Mediated Phosphorylation of FcR1 Gamma

Binding of Syk Tyrosine Kinase

SYK Autophosphorylates

P-Y348-SYK Dissociates

P-Y348-SYK Binds VAV Family

P-Y348-SYK Phosphorylates VAV Family

VAV1 Is a GEF for Rho/Rac Family GTPases

VAV2 Is a GEF for Rho/Rac Family Kinases

VAV3 Is a GEF for Rho/Rac Family Kinases

Syk/Lck Phosphorylate LAT

Syk Activation Leads to SLP-76 Activation

SLP-76 Stimulates PLC Gamma 2

P-SLP-76 Binds VAV

PLC Gamma 2-Mediated PIP2 Hydrolysis

PI(3,4,5)P3 Binds VAV1,2,3

PIP2 Binds Inhibiting VAV

GPVI Stimulates PI3K Beta, Gamma

PI3K Alpha, Beta, Gamma Convert PIP2 to PIP3

PDPK1 Binds PRKCZ

PDPK1 Activates PRKCZ

G6B Binds PTPN6,PTPN11

CLEC1B Dimer Binds PDPN

Unknown Kinase Phosphorylates CLEC1B Dimer:PDPN

P-Y7-CLEC1B Dimer:PDPN Binds SYK

PIP3 Recruits PDPK1 to the Membrane

Exact Match

https://identifiers.org/reactome:R-H ...