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Thrombin Signalling Through Proteinase Activated Receptors (PARs) - Ontify

Thrombin Signalling Through Proteinase Activated Receptors (PARs)

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-456926).

Statements about Thrombin Signalling Through Proteinase Activated Receptors (PARs)

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Instance Of

Biological Pathway

Part Of

Platelet Activation, Signaling and Aggregation

Has Part(s)

16 items

Activated Thrombin (Factor IIa) Cleaves PAR3,4, Activating Them

Thrombin-Activated PARs Binds G-Protein Gq

Thrombin-Activated PARs Activate Gq

Thrombin-Activated PARs:Gq (Active) Dissociate

Thrombin-Activated PARs Binds G-Protein G12/13

Thrombin-Activated PARs Activate G12/13

Thrombin-Activated PARs:G12/13 (Active) Dissociate

F2R Binds ARRB1

F2R Binds ARRB2

F2R:ARRB1 Binds MAPKs, SRC-1

F2R:ARRB2 Binds MAPKs, SRC-1

SRC-1 Is Activated (in F2R:ARRB1:MAPKs:SRC-1)

SRC-1 Bound to ARRB2 Is Not Activated

Activated SRC-1 Activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)

Activated Thrombin (Factor IIa) Cleaves F2R (PAR1), Activating It

Pro-F2R Binds Vorapaxar

Exact Match

https://identifiers.org/reactome:R-H ...