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PIWI-Interacting RNA (piRNA) Biogenesis - Ontify

PIWI-Interacting RNA (piRNA) Biogenesis

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5601884).

Statements about PIWI-Interacting RNA (piRNA) Biogenesis

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Instance Of

Biological Pathway

PiRNA Metabolic Process

Part Of

Gene Silencing by RNA

Has Part(s)

16 items

RNA Polymerase II Polymerizes Primary piRNA Transcript

Primary piRNA Transcript Translocates From Nucleoplasm to Cytosol

PLD6 Dimer Cleaves Primary piRNA Transcript to Pre-piRNA

Complexed PIWIL1 Binds Pre-piRNA

Complexed PIWIL2 Binds Pre-piRNA

Unknown Nuclease Cleaves Pre-piRNA in 4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH

HENMT1 Methylates 2' Hydroxyl at 3' End of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH

Unknown Nuclease Cleaves Pre-piRNA in ASZ1:DDX4:MOV10L1:6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12

HENMT1 Methylates 2' Hydroxyl at 3' End of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1

Complexed PIWIL2:2'-O-Methyl-piRNA Cleaves Transposon RNA

Complexed PIWIL2 Binds Cleaved Transposon RNA

Unknown Nuclease Cleaves Cleaved Transposon RNA in 6xMeR-PIWIL2:cleaved Transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1

Complexed PIWIL4 Binds Cleaved Transposon RNA

Unknown Nuclease Cleaves Cleaved Transposon RNA Bound in MeR-PIWIL4:cleaved Transposon RNA:TDRD9:MAEL:TDRKH

HENMT1 Methylates 2' Hydroxyl at 3' End of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH

MeR-PIWIL4:2'-O-Methyl-piRNA:TDRD9:MAEL:TDRKH Dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL Translocate From Cytosol to Nucleus in an Unknown Association and Order of Events

Exact Match

https://identifiers.org/reactome:R-H ...