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RUNX1 Regulates Transcription of Genes Involved in Differentiation of HSCs - Ontify

RUNX1 Regulates Transcription of Genes Involved in Differentiation of HSCs

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8939236).

Statements about RUNX1 Regulates Transcription of Genes Involved in Differentiation of HSCs

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Instance Of

Biological Pathway

Regulation of Hematopoietic Stem Cell Differentiation

Part Of

Transcriptional Regulation by RUNX1

Has Part(s)

15 items

KMT2A (MLL) Binds RUNX1

RUNX1:CBFB:KMT2A Binds SPI1 (PU.1) Gene

KMT2A Trimethylates Nucleosomes at the SPI1 Gene Locus Producing H3K4Me3 Mark

SPI1 (PU.1) Gene Transcription Is Stimulated by RUNX1:CBFB:KMT2A

RUNX1 Binds the Core TAL1 Complex

RUNX1-Containing TAL1 Complex Binds the MYB Gene Enhancer

MYB Gene Transcription Is Stimulated by the RUNX1-Containing TAL1 Complex

RUNX1 Binds YAP1

The Complex of RUNX1 and YAP1 Binds the ITCH Gene Promoter

ITCH Gene Expression Is Stimulated by RUNX1 and YAP1

ABL1 Phosphorylates YAP1

YAP1 Binds TP73

TP73 Tetramer Translocates to the Nucleus

ITCH Polyubiquitinates TP73

26S Proteasome Degrades TP73 Polyubiquitinated by ITCH

Exact Match

https://identifiers.org/reactome:R-H ...