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TP53 Regulates Metabolic Genes - Ontify

TP53 Regulates Metabolic Genes

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5628897).

Statements about TP53 Regulates Metabolic Genes

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Instance Of

Biological Pathway

Part Of

Transcriptional Regulation by TP53

Has Part(s)

34 items

GPX2 Catalyzes 2 Glutathione, Reduced + H2O2 => Glutathione, Oxidized + 2 H2O

Glutathione (Oxidized) + NADPH + H+ => 2 Glutathione (Reduced) + NADP+

PRDX1,2,5 Catalyze TXN Reduced + H2O2 => TXN Oxidized + 2H2O

Thioredoxin, Oxidized + NADPH + H+ => Thioredoxin, Reduced + NADP+

TP53 Binds the TIGAR Gene

TP53 Stimulates TIGAR Expression

TIGAR Converts D-Fructose-2,6-Bisphosphate to D-Fructose 6-Phosphate

D-Fructose 6-Phosphate <=> Alpha-D-Glucose 6-Phosphate

Alpha-D-Glucose 6-Phosphate + NADP+ => D-Glucono-1,5-Lactone 6-Phosphate + NADPH + H+

MiR-26A microRNAs Bind PTEN mRNA

PTEN mRNA Translation Negatively Regulated by microRNAs

TP53 Binds the PTEN Promoter

PTEN Gene Transcription Is Stimulated by TP53

TP53 Binds Regulatory Elements of SESN1,2,3 Genes

TP53 Stimulates Expression of SESN1,2,3 Genes

PRDX1 Overoxidizes

SESN1,2,3 Bind Overoxidized PRDX1

P-AMPK Phosphorylates TSC1:TSC2

RHEB in mTORC1:RHEB:GTP Hydrolyses GTP

SESN1,2,3 Bind AMPK

TP63/TP53 Stimulates Transcription of DDIT4 Gene

TP63/TP53 Bind the DDIT4 Gene Promoter

Formation of TSC1:TSC2 Complex

AKT Phosphorylates TSC2, Inhibiting It

P-S939,T1462-TSC2 Binding to 14-3-3 Dimer Is Negatively Regulated by DDIT4

DDIT4 Binds 14-3-3 Dimer

TP53 Binds the SCO2 Gene

TP53 Stimulates SCO2 Gene Transcription

Electron Transfer From Reduced Cytochrome C to Molecular Oxygen

TP53 Binds the RRM2B Gene

TP53 Stimulates Transcription of RRM2B Gene

TP53 Binds the GLS2 Promoter

TP53 Stimulates GLS2 Transcription

Glutamine + H2O => Glutamate + NH4+ [GLS]

Exact Match

https://identifiers.org/reactome:R-H ...