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Downregulation of SMAD2/3:SMAD4 Transcriptional Activity
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2173795).
Statements about
Downregulation of SMAD2/3:SMAD4 Transcriptional Activity
Instance Of
Biological Pathway
Negative Regulation of Transcription by RNA Polymerase II
Part Of
Transcriptional Activity of SMAD2/SMAD3:SMAD4 Heterotrimer
Has Part(s)
27 items
SKI/SKIL Binds SMAD Complex, Suppressing TGF-Beta Signaling
SMAD2/3 Activation Induces Binding of RNF111/SMURF2 to SKI/SKIL
Ubiquitination of SKI/SKIL by RNF111/SMURF2
Degradation of Ubiquitinated SKI/SKIL
TRIM33 Monoubiquitinates SMAD4
USP9X (FAM) Binds to Ubiquitinated SMAD4
NEDD4L Binds Phosphorylated Linker Region of SMAD2/3
USP9X (FAM) Deubiquitinates SMAD4
NEDD4L Ubiquitinates SMAD2/3
Degradation of SMAD2/3:SMAD4 Complex
SMURF2 Binds SMAD3 Phosphorylated in the Linker Region
SMURF2 Monoubiquitinates SMAD3
Dephosphorylated SMAD2/3 Translocates to the Cytosol
STAT1 Stimulates SMAD7 Gene Transcription
MAPK1 and MAPK3 Phosphorylate SMAD2 and SMAD3
Exact Match
https://identifiers.org/reactome:R-H ...
Ubiquitin-Dependent Degradation of the SMAD Complex Terminates TGF-Beta Signaling
ATP1B4 Binds SNW1
Ubiquitinated SMAD4 Translocates From the Nucleus to the Cytosol
PPM1A Dephosphorylates Nuclear SMAD2/3
PPM1A Protein Phosphatase Binds Phosphorylated SMAD2/3
SMAD7 Binds SERPINE1 Gene Promoter
TGIF Recruits HDAC1 to SMAD2/3:SMAD4 Heterotrimer
WWTR1:p-2S-SMAD2,3:SMAD4 Binds SMAD7 Gene Promoter
PARP1 ADP-Ribosylates SMAD3 and SMAD4
TRIM33 (Ectodermin) Binds SMAD Heterotrimer in the Nucleus
WWTR1:SMAD Stimulates Transcription of SMAD7
PARP1 Binds SMAD2/3:SMAD4 Heterotrimer
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