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SMAD2/SMAD3:SMAD4 Heterotrimer Regulates Transcription - Ontify
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SMAD2/SMAD3:SMAD4 Heterotrimer Regulates Transcription
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2173796).
Statements about
SMAD2/SMAD3:SMAD4 Heterotrimer Regulates Transcription
Instance Of
Biological Pathway
Positive Regulation of Transcription by RNA Polymerase II
Part Of
Transcriptional Activity of SMAD2/SMAD3:SMAD4 Heterotrimer
Has Part(s)
24 items
Phosphorylated SMAD2 and SMAD3 Form a Complex with SMAD4
The SMAD2/3:SMAD4 Complex Transfers to the Nucleus
Phosphorylation of SMAD2 and SMAD3 Linker Regions by CDK8 or CDK9
WWTR1:SMAD Translocates to the Nucleus
RNF111 Binds SMAD7
RNF111 Ubiquitinates SMAD7
Degradation of Ub-SMAD7
WWTR1:p-2S-SMAD2,3:SMAD4 Binds SERPINE1 Gene Promoter
Exact Match
https://identifiers.org/reactome:R-H ...
WWTR1 Binds SMAD2/3:SMAD4 Heterotrimer
COL1A2 Gene Expression Is Stimulated by P-2S-SMAD3:p-2S-SMAD3:SMAD4
P-2S-SMAD2,3:SMAD4 Binds JUNB Gene Promoter
SMAD2/3:SMAD4 Heterotrimer Forms a Complex with RBL1, E2F4/5 and DP1/2
P-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 Binds MYC Gene Promoter
WWTR1:SMAD Stimulates Transcription of SERPINE1 While TGIF:SMAD and SMAD7 Inhibit It
YBX1 Binds COL1A2 Gene Promoter
FURIN Translocates to the Plasma Membrane
P-2S-SMAD2,3:SMAD4:SP1 Binds CDKN2B Gene Promoter
P-2S-SMAD3:p-2S-SMAD3:SMAD4 Forms a Complex with SP1 and EP300 at the COL1A2 Gene Promoter
MYC Trancscription Is Negatively Regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 Complex
FURIN Gene Transcription Is Stimulated by SMAD2/SMAD3:SMAD4
SMAD2/3:SMAD4 Heterotrimer Binds SP1
SMAD2/3:SMAD4:SP1 Complex Stimulates Transcription of CDKN2B
MEN1 Binds SMAD2/3:SMAD4 Heterotrimer
SMAD2/3:SMAD4 Complex Positively Regulates JUNB Transcription
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