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Deregulated CDK5 Triggers Multiple Neurodegenerative Pathways in Alzheimer's Disease Models - Ontify
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Deregulated CDK5 Triggers Multiple Neurodegenerative Pathways in Alzheimer's Disease Models
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8862803).
Statements about
Deregulated CDK5 Triggers Multiple Neurodegenerative Pathways in Alzheimer's Disease Models
Instance Of
Biological Pathway
Part Of
Neurodegenerative Diseases
Has Part(s)
22 items
Calpain Activation
Calpain Cleaves P35 to P25
CAST Binds Ca2+ Bound Calpain
CDK5:p25 Phosphorylates GOLGA2
Exact Match
https://identifiers.org/reactome:R-H ...
CDC25C Binds YWHAE (14-3-3-Epsilon)
APP Gene Expression
Influx of Extracellular Calcium
CDK5:p25 Phosphorylates FOXO3
CDK5:p25 Phosphorylates JUN
P25-Bound CDK5 Phosphorylates CDC25A
CDK5:p25 Phosphorylates PRDX2
P25-Bound CDK5 Phosphorylates CDC25C
Phosphorylated FOXO3 Translocates to the Nucleus
FASLG (FasL) Gene Expression
BCL2L11 (BIM) Gene Expression
CDK5 Binds P25
CDK5:p25 Translocates to the Nucleus
CDK5:p25 Phosphorylates Lamin B1
CDK5:p25 Phosphorylates Lamin A
P25-Bound CDK5 Phosphorylates CDC25B
CDK5:p25 Phosphorylates PRDX1
SOD2 (MnSOD) Gene Expression
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