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Defective CFTR Causes Cystic Fibrosis - Ontify
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Defective CFTR Causes Cystic Fibrosis
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5678895).
Statements about
Defective CFTR Causes Cystic Fibrosis
Instance Of
Biological Pathway
Part Of
ABC Transporter Disorders
Has Part(s)
CFTR F508del Binds Components of the ERAD Machinery for Ubiquitination and Degradation
RNF5 and RNF185 Ubiquitinate CFTR F508del
VCP-Catalyzed ATP Hydrolysis Promotes the Translocation of CFTR F508del Into the Cytosol
CFTR F508del Is Degraded by the 26S Proteasome
CFTR F508del Binds CFTR Correctors
Exact Match
https://identifiers.org/reactome:R-H ...
Ivacaftor:CFTR G551D Transports Cl- From Cytosol to Extracellular Region
Defective CFTR Does Not Transport Cl- From Cytosol to Extracellular Region
Ivacaftor Binds CFTR G551D
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