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Paradoxical Activation of RAF Signaling by Kinase Inactive BRAF - Ontify

Paradoxical Activation of RAF Signaling by Kinase Inactive BRAF

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6802955).

Statements about Paradoxical Activation of RAF Signaling by Kinase Inactive BRAF

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Instance Of

Biological Pathway

Part Of

Oncogenic MAPK Signaling

Has Part(s)

Inactive BRAF Mutants:mutant RAS:GTP Bind RAF1

RAS:GTP:p-RAF Complexes Paradoxically Bind MAP2Ks and MAPKs

Dissociation of Paradoxically Activated RAS:BRAF Complexes

Exact Match

https://identifiers.org/reactome:R-H ...

Inactive BRAF Mutants Bind Mutant RAS:GTP

RAS:GTP:inactive P-RAF Complexes Phosphorylate MAP2Ks

Activated MAP2Ks Phosphorylate MAPKs Downstream of Inactive BRAF Mutants

RAF Is Paradoxically Phosphorylated Downstream of Kinase-Inactive RAF