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Signaling by Cytosolic FGFR1 Fusion Mutants - Ontify

Signaling by Cytosolic FGFR1 Fusion Mutants

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1839117).

Statements about Signaling by Cytosolic FGFR1 Fusion Mutants

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Instance Of

Biological Pathway

Part Of

FGFR1 Mutant Receptor Activation

Has Part(s)

14 items

FGFR1OP-FGFR1 Phosphorylates STAT1 and STAT3

Exact Match

https://identifiers.org/reactome:R-H ...

Dimerization of Cytosolic FGFR1 Fusion Proteins

Phosphorylation of STAT5 by Cytosolic FGFR1 Fusions

BCR-FGFR1 Fusion:GRB2:p-GAB2:PIK3R1 Binds PIK3CA

Cytosolic FGFR1 Fusion Proteins Bind PIK3R1

Phosphorylation of Cytosolic FGFR1 Fusion Dimers

Tyrosine Kinase Inhibitors Bind and Inhibit Cytosolic FGFR1 Fusion Dimer Phosphorylation

Activated Cytosolic FGFR1 Fusions Bind PIK3CA

P-BCR-pFGFR1 Binds GRB2:GAB2

BCR-FGFR1:GRB2:p-GAB2 Binds PIK3R1

P-BCR-P-FGFR1 Phosphorylates GAB2

Phosphorylation of BCR Moiety of BCR-FGFR1

Cytosolic FGFR1 Fusion Protein-Associated PI3K Phosphorylates PIP2 to PIP3

BCR-FGFR1-Associated PI3K Phosphorylates PIP2 to PIP3.