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Fanconi Anemia Pathway

Fanconi Anaemia Pathway

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6783310).

Statements about Fanconi Anemia Pathway

Instance Of

Biological Pathway

Interstrand Cross-Link Repair

Part Of

Has Part(s)

14 items

FANCM Binds FAAP24

FANCM:FAAP24 and APITD1:STRA13 Bind ICL-DNA

FA Core Complex Assembles at DNA Interstrand Crosslinks (ICLs)

FANCD2 Binds FANCI

FANCD2:FANCI Complex and UBE2T Bind ICL-DNA Associated with the FA Core Complex

Monoubiquitination of FANCD2:FANCI

The Complex of ATR and ATRIP Is Recruited to ICL-DNA

ATR Phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA

FANCD2 Deubiquitination by USP1:WDR48

DNA Nucleases Bind Monoubiquitinated ID2 Complex

DNA Nucleases Unhook the Interstrand Crosslink (ICL)

POLN Binds ICL-DNA

Translesion Synthesis Across Unhooked ICL by POLN

Drug-Induced Formation of DNA Interstrand Crosslinks

Exact Match

https://identifiers.org/reactome:R-H ...

Studied By

Has Use

DNA Replication

Described by Source

Current Biology

:bug2: http://wikiba.se/ontology#ExternalId

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