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Mismatch Repair (MMR) Directed by MSH2:MSH3 (MutSbeta)
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5358606).
Statements about
Mismatch Repair (MMR) Directed by MSH2:MSH3 (MutSbeta)
Instance Of
Biological Pathway
DNA Mismatch Repair
Part Of
Mismatch Repair
Has Part(s)
DNA Polymerase Delta Polymerizes DNA Across Single Stranded Gap
DNA Ligase I Ligates Single Stranded Nick in Double Stranded DNA
Exact Match
https://identifiers.org/reactome:R-H ...
Formation of MSH2:MSH3 Complex
MLH1:PMS2 Makes Single Strand Incision Near Insertion/Deletion Loop of 2 Bases or More
EXO1 Interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha)
MSH2:MSH3 Recruits MLH1:PMS2 to Mismatch and Interacts with PCNA
EXO1 Interacting with MSH2:MSH3 Excises DNA Strand Containing an Insertion/Deletion Loop (IDL)
MSH2:MSH3 Exchanges ADP for ATP
MSH2:MSH3 Binds Insertion/Deletion Loop of 2 Bases or More
