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Mismatch Repair (MMR) Directed by MSH2:MSH6 (MutSalpha) - Ontify
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Mismatch Repair (MMR) Directed by MSH2:MSH6 (MutSalpha)
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5358565).
Statements about
Mismatch Repair (MMR) Directed by MSH2:MSH6 (MutSalpha)
Instance Of
Biological Pathway
DNA Mismatch Repair
Part Of
Mismatch Repair
Has Part(s)
10 items
Exact Match
https://identifiers.org/reactome:R-H ...
Formation of MSH1:PMS2 Complex
DNA Ligase I Ligates Single Stranded Nick in Double Stranded DNA
Formation of MSH2:MSH6 Complex
EXO1 Interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)
EXO1 Interacting with MSH2:MSH6 Excises Single Strand DNA Containing a Mismatch
MLH1:PMS2 Makes Single Strand Incision Near 1-2 Base Mismatch
DNA Polymerase Delta Polymerizes DNA Across Single Stranded Gap
MSH2:MSH6 Exchanges ADP for ATP
MSH2:MSH6 Recruits MLH1:PMS2 to Mismatch and Interacts with PCNA
MSH2:MSH6 Binds 1 Base Mismatch or 1-2 Base Insertion/Deletion Loop
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