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Nonhomologous End-Joining (NHEJ) - Ontify
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Nonhomologous End-Joining (NHEJ)
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5693571).
Statements about
Nonhomologous End-Joining (NHEJ)
Instance Of
Biological Pathway
Double-Strand Break Repair via Nonhomologous End Joining
Part Of
DNA Double-Strand Break Repair
Has Part(s)
13 items
RIF1 and PAX1IP Bind TP53BP1 at DNA DSBs
Association of Ku Heterodimer with Ends of DNA Double-Strand Break
Association of DNA-PKcs with Ku-Bound Ends of DNA Double-Strand Breaks - Synapsis
TP53BP1 Recruits DCLRE1C to ATM
Activated ATM Phosphorylates DCLRE1C
DNA-PKcs Autophosphorylates
DCLRE1C Binds PRKDC:XRCC5:XRCC6 at DNA DSBs
PRKDC Phosphorylates DCLRE1C at DNA DSBs
DCLRE1C (ARTEMIS) Processes DNA DSB Ends
TDP1 and TDP2 Process Unligatable DSB Ends
XRCC4:LIG4, NHEJ1 and POLL or POLM Bind DNA DSBs in NHEJ
POLL or POLM Extends Aligned DNA DSB Ends to Fill Gaps
XRCC4:LIG4 Ligates DNA DSB Ends During NHEJ
Exact Match
https://identifiers.org/reactome:R-H ...
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