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APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway - Ontify

APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5649702).

Statements about APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

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Instance Of

Biological Pathway

Base-Excision Repair, Gap-Filling

Part Of

Resolution of Abasic Sites (AP Sites)

Has Part(s)

POLB Excises the NEIL1,NEIL2-Bound AP Site (5'dRP)

LIG3:XRCC1 and PNKP Bind NEIL1,NEIL2:POLB:SSB(3'Pi)-Gap-dsDNA

PNKP Hydrolyzes the Terminal 3'Pi at the NEIL1,NEIL2-Generated Single Strand Break (SSB)

LIG3 Ligates NEIL1,NEIL2-Generated Single Strand Break

LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP Dissociate From the BER Site

Exact Match

https://identifiers.org/reactome:R-H ...

NEIL1,NEIL2 Displace OGG1 From AP-dsDNA

NEIL1,NEIL2 Incises DNA Strand 5' To the AP Site

NEIL1,NEIL2 Recruits POLB to Incised AP Site

POLB Incorporates a Single Nucleotide in Place of Excised AP Residue in NEIL1,NEIL2-Mediated AP Site Resolution