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Circadian Clock - Ontify
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Circadian Clock
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-400253).
Statements about
Circadian Clock
Instance Of
Biological Pathway
Circadian Rhythm
Has Part(s)
37 items
RORA Activates Gene Expression
BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression
NR1D1 (REV-ERBA) Represses Gene Expression
Expression of CLOCK
Expression of ARNTL (BMAL1)
Expression of NPAS2
BMAL1 Binds CLOCK,NPAS2 Forming BMAL1:CLOCK,NPAS2 Heterodimer
BMAL1:CLOCK,NPAS2 Heterodimer Is Phosphorylated and Translocates to the Nucleus
Expression of RORA (ROR-Alpha)
CRY Proteins Stabilize Unphosphorylated BMAL1:CLOCK,NPAS2
Formation of CRY:PER:Kinase Complex
Beta-TrCP1 Binds Phosphorylated PER Proteins
CRY:PER Heterodimer Binds the BMAL1:CLOCK/NPAS2 Heterodimer
CSNK1E,CSNK1D Phosphorylate CRY and PER Proteins
CRY:PER:Kinase Complex Translocates to the Nucleus
FBXL3 Binds Phosphorylated CRY Proteins
CRY Proteins Are Ubiquitinylated
Expression of PPARGC1A (PGC-1alpha)
BTRC:CUL1:SKP1 (SCF-Beta-TrCP1) Ubiquitinylates PER Proteins
P-BMAL1:p-CLOCK,NPAS2 Binds CRY1 Gene
Expression of CRYPTOCHROME-1
Expression of CRYPTOCHROME-2
Expression of PERIOD-1
P-BMAL1:p-CLOCK,NPAS2 Binds PER1 Gene
P-BMAL1:p-CLOCK,NPAS2 Binds PER2 Gene
Expression of PERIOD-2
P-BMAL1:p-CLOCK,NPAS2 Binds NR1D1 Gene
Expression of NR1D1 (REV-ERBA)
P-BMAL1:p-CLOCK,NPAS2 Binds RORA Gene
RORA, EP300, PPARGC1A, NRIP1 Bind ARNTL (BMAL1) Gene
RORA, EP300 Bind NPAS2 Gene
RORA, EP300, PPARGC1A Bind NR1D1 Gene
NR1D1 (REV-ERBA) Binds Heme, the ARNTL Gene, and Recruits Corepressors.
NR1D1 (REV-ERBA) Binds Heme, the NPAS2 Gene, and Recruits Corepressors
NR1D1 (REV-ERBA) Binds Heme, the CLOCK Gene, and Recruits Corepressors
NR1D1 (REV-ERBA) Binds Heme, the NR1D1 Gene, and Recruits Corepressors
NR1D1 (REV-ERBA) Binds Heme, the PPARGC1A Gene, and Recruits Corepressors
Exact Match
https://identifiers.org/reactome:R-H ...
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