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HSP90 Chaperone Cycle for Steroid Hormone Receptors (SHR) in the Presence of Ligand - Ontify

HSP90 Chaperone Cycle for Steroid Hormone Receptors (SHR) in the Presence of Ligand

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-3371497).

Statements about HSP90 Chaperone Cycle for Steroid Hormone Receptors (SHR) in the Presence of Ligand

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Instance Of

Biological Pathway

Cellular Response to Steroid Hormone Stimulus

Part Of

Cellular Responses to Stress

Has Part(s)

22 items

ATP Hydrolysis by HSP70

STIP1(HOP) Binds HSP90 and HSP70:HSP40:nascent Protein

HSP70 Binds to HSP40:nascent Protein

ATP Binding to HSP90 Triggers Conformation Change

FKBP5 Binds HSP90:ATP:STIP1:HSP70:nascent Protein

FKBP4 Binds HSP90:ATP:STIP1:HSP70:nascent Protein

P23 (PTGES3) Binds HSP90:ATP:FKBP4:nascent Protein

FKBP4 Replaces FKBP5 Within HSP90:ATP:FKBP5:unfolded Protein

P23 (PTGES3) Binds HSP90:ATP:FKBP5:nascent Protein

NR3C2 Ligands Bind NR3C2 (in the HSP90 Chaperone Complex)

HSP90:ATP:p23:FKBP52:SHR:SH Translocates to the Nucleus

ATP Hydrolysis by HSP90

NR3C1 Ligands Bind NR3C1 (in the HSP90 Chaperone Complex)

NR3C1 Binds NR3C1 Agonists

Androgens Binds AR (in the HSP90 Chaperone Complex)

PGR Binds PGR Agonists

AR Binds AR Antagonists

P4 Bind PGR (in the HSP90 Chaperone Complex)

PGR Binds PGR Antagonists

NR3C2 Binds NR3C2 Antagonists

AR Binds AR Agonists

NR3C2 Binds Fludrocortisone

Exact Match

https://identifiers.org/reactome:R-H ...