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Senescence-Associated Secretory Phenotype (SASP)
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2559582).
Statements about
Senescence-Associated Secretory Phenotype (SASP)
Instance Of
Biological Pathway
Part Of
Cellular Senescence
Has Part(s)
22 items
Association of INK4 Family Proteins with CDK4/6
CDKN1A (P21) Prevents Phosphorylation of Cdh1 by Cyclin A:Cdk2
CDKN1A (P21) Prevents Association of Cyclin A:Cdk2 with Cdh1
Cdh1:APC/C Complex Binds EHMT1:EHMT2
Cdh1:APC/C Ubiquitinates EHMT1 and EHMT2
EHMT1:EHMT2 Methylates IL6 Promoter
EHMT1:EHMT2 Methylates IL8 Promoter
ERK1/2/5 Activate RSK1/2/3
MAPK3 (ERK1) and MAPK1 (ERK2) Phosphorylate CEBPB
RPS6KA1/2/3 Phosphorylates CEBPB on S321
CEBPB Homodimerization
Regulation of IL6 Transcription
Activated CEBPB and NFKB Complex Bind IL6 Promoter
Activated STAT3 Positively Regulates CEBPB Transcription
Stimulation of IL8 Transcription in Senescent Cells
Activated CEBPB and NFKB Complex Bind IL8 Promoter
AP-1 Transcription Factor Binds IGFBP7 Promoter
AP-1 Stimulates Transcription of IGFBP7
Activated CEBPB Binds CDKN2B Promoter
Activated CEBPB Stimulates Transcription of CDKN2B
AP-1 Transcription Factor Binds IL1A Promoter
AP-1 Stimulates IL1A Transcription
Exact Match
https://identifiers.org/reactome:R-H ...
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